Top Mississippi River Tours & Cruises in 2028

Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.

Aboard American Symphony, cruise round-trip from New Orleans for 8 days through Louisiana and Mississippi. Tour antebellum mansions in Natchez, walk Vicksburg's Civil War battlefields, and take an optional swamp boat ride near Oak Alley — a good match for travelers drawn to Southern history and Cajun culture.

Embark on a 9-day cruise aboard American Heritage from Memphis to New Orleans along the Lower Mississippi River. Visit Cleveland, Vicksburg, Natchez, Baton Rouge, and Oak Alley. Explore Civil War landmarks, historic homes, museums, plantations, and Louisiana wetlands while discovering the history, music, and culture of the American South.

Cruise on a 9-day voyage aboard American Melody along the Mississippi River. Visit Cleveland, Vicksburg, Natchez, Baton Rouge, and Oak Alley through included excursions featuring museums, Civil War sites, historic homes, and music heritage. This itinerary combines Mississippi River scenery with Southern history and culture.

Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Experience a 9-day cruise aboard American Splendor from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Embark on a 16-day cruise linking two rivers, the Mississippi and Cumberland, between New Orleans and Nashville aboard American Symphony. Visit Civil War battlefields, antebellum estates, and the birthplaces of jazz, blues, and country music.

Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.

Explore a 16-day Mississippi and Ohio River cruise from St. Louis to Pittsburgh aboard American Melody. Visit Paducah, Henderson, Evansville, Louisville, Madison, Cincinnati, Maysville, and Marietta, with time for museums, historic districts, Underground Railroad sites, regional art, river heritage, and American history. Discover local history.

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.