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Ruins in Colon, Panama

Best Small Ship Cruises to Colon

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Discover the best small ship cruises to Colon—a more personal, crowd-free way to explore stunning coastlines and hidden ports that big ships can't reach. At Adventure Life, we work with top-rated cruise lines visiting places like , and we’ll help match you with the perfect ship and itinerary based on what you love. These cruises start at $323 for trips lasting 5 to 13 days in 2026. Tell us about your dream Colon cruise, and our travel experts will help make it a reality.
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    • Colon
Panama Canal
from $6,320
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Costa Rica and the Panama Canal

Eastbound - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Kayaking, Horseback Riding, Stand Up Paddle Boarding
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
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Explore beautiful Costa Rica
from $6,420
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Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys

Colon - Puntarenas - 8 Day Itinerary aboard Le Champlain
  • Discover San Blas
  • Experience Panama Canal
  • Explore Fuerte Amador
  • Visit Darien National Park
Starts / Ends
Colon / Puntarenas
Activities
Snorkeling
Activity Level
Variable
Join this 8-day cruise aboard Le Champlain to explore the natural wonders and cultural heritage of Panama and Costa Rica, including the white sands of Holandes Cayes, the iconic Panama Canal, and Panama City's historic Old Quarter.
Cruise Details
0
from $10,170
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Secrets of Central America

Colón - Puntarenas - 11 Day Itinerary aboard Le Champlain
  • Discover National Parks
  • Sail through the Panama Canal
  • Encounter with Emberas tribe
  • Visit San Blas archipelago
Starts / Ends
Colon / Puntarenas
Activities
Archaeological Site Visits
Activity Level
Variable
Join this 11-day Secrets of Central America cruise and explore Panama and Costa Rica, starting at San Lorenzo’s Fort and traveling from the Atlantic to the Pacific. Visit the San Blas Islands, the Pearl Islands, Darien National Park, and cross the Panama Canal. Meet local communities, and discover the biodiversity of Rio Esquinas and Curú Nature Reserve.
Cruise Details
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Panama Canal
from $12,795
EBD
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Costa Rica and The Panama Canal

San Jose - Panama - 12 Day Itinerary aboard Sylvia Earle
  • Cross Panama Canal
  • Explore biodiverse rainforests
  • Visit Coiba National Park
  • Enjoy Manuel Antonio National Park
Starts / Ends
San Jose / Panama City
Activities
Village Visits
Activity Level
Variable
Embark on a 12-day cruise aboard the Sylvia Earle to explore Central America's rich ecosystems, from Costa Rica's diverse wildlife to Panama's vibrant coral reefs. Experience a memorable daylight transit through the historic Panama Canal, witnessing this engineering marvel firsthand.
Cruise Details
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Look for unique birds and other wildlife in the rain forest!
from $12,955
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Natural Wonders, Engineering Marvels

Puntarenas - Colon - 13 Day Itinerary aboard Sea Cloud Spirit
  • Explore Nicoya Peninsula beaches
  • Visit Pearl Islands Discover Pea
  • Discover Marina Flamingo
  • Relax at Playa Panama
  • Sail through the Panama Canal
Starts / Ends
Puntarenas / Colon
Activities
Hiking, Wildlife Viewing, Rainforest Exploration, Small Ship Sailing, Fishing
Activity Level
Variable
Experience the essence of “Pura Vida” on a 13-day Panama cruise from Puntarenas to Colon. Visit Punta Leona, Marina Flamingo, Playa Panama, Quepos, Puerto Jimenez, the Pearl Islands, and the San Blas Archipelago, exploring rainforests, beaches, & marinas while encountering diverse wildlife and witnessing the engineering marvel of the Panama Canal.
Cruise Details
0
Mountains by the ocean in St Lucia
from $8,490
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Panama, Colombia & Caribbean Islands

Colon to Fort-de-France - 13 Day Itinerary aboard Le Champlain
  • Sail through the Central America.
  • See San Blas, Bonaire & Grenadines
  • Experience swim and snorkel.
  • Learn traditions of the Kuna people
  • Dive with an experienced instructor
Starts / Ends
Colon / Fort de France
Activities
Land & Sea Exploration
Activity Level
Variable
Join Le Bellot for an exceptional 13-day cruise sailing from Colón to Fort-de-France. This itinerary gives you the opportunity to appreciate the richness and diversity of Afro-Caribbean cultures, an azure blue sky, and white-sand beaches. Visit stunning ports, including Portobelo, Cartagena, Santa Marta, Mayreau Island, and Soufriére.
Cruise Details
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Transitioning the Panama Canal
from $323
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Panama Canal Full Transit

1 Day Itinerary
  • See the Panama City skyline
  • Learn the history of the canal
Activity Level
Relaxed
This Panama City one-day tour takes you on the incredible journey from the Atlantic Ocean all the way to the Pacific Ocean, traversing two impressive locks via the manmade wonder that is the Panama Canal.
Tour Details
0
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