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Panama's turquoise waters

Portobelo Small Ship Cruises

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Experience the allure of Panama and its surrounding wonders with Adventure Life's selection of 5 small ship cruises for 2026. Join us on a cruise journey through the enchanting Caribbean coast, ancient colonial cities, and lush rainforests. From exploring the UNESCO-listed streets of Cartagena de Indias and diving into the protected waters of Barbados to meeting the Indigenous people of Guna Yala and marveling at the colonial architecture of Willemstad, each moment is filled with cultural and natural marvels. Engage in wildlife viewing, snorkeling in crystal-clear waters, and immerse yourself in the rich biodiversity of the region. With activities suitable for all travelers, this adventure offers a relaxed pace to discover the captivating nature and history of Panama and its surroundings. Don't miss this opportunity to embark on a seamless journey through this tropical paradise. Contact one of Adventure Life's tour specialists for help planning your next unforgettable trip.
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    • Portobelo
Explore beautiful Costa Rica
from $6,801
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Exploring Arenal Volcano, Pearl Islands and the Panama Canal

San Jose to Panama - 9 Day Itinerary aboard National Geographic Quest
  • Arenal Volcano exploration
  • Relax in Ecotermales hot springs
  • Pearl Islands snorkeling
  • Navigate the Panama Canal
Starts / Ends
San Jose / Panama City
Activities
Land & Sea Exploration
Activity Level
Variable
Arrive in San Jose, transfer to La Fortuna and start the 9-day land and sea adventure. Explore Arenal Volcano and rainforest trails. Fly to Panama City and embark National Geographic Quest. Kayak, hike, and cruise the Panama Canal, Gatun Lake, and Pearl Islands while snorkeling, exploring fortresses, and discovering tropical wildlife.
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Balboa
from $3,150
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Panama to Aruba

12 Day Itinerary aboard Star Clipper
  • Transit the Panama Canal locks
  • Walk colonial Balboa streets
  • Explore forts in Portobelo
  • Visit San Blas and Guna villages
  • See Cartagena and Santa Marta
Starts / Ends
Balboa / Oranjestad
Activities
Local Market Visits, Small Ship Sailing
Activity Level
Variable
Sail the Panama Canal on a 10-day Star Clippers cruise through Central America. Begin in Balboa, then transit the Panama Canal and see the locks in action. Explore Spanish forts in Portobelo, meet the Guna people in the San Blas Islands, and discover Colombia’s coastal cities of Cartagena and Santa Marta. Enjoy scenic days under sail.
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Sunset over Cartagena, Colombia
from $6,450
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Panama and Colombia: Exploring the Caribbean Coast

Panama to Cartagena - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, Archipelago, and more.
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Guests explore by zodiac cruise in Portobelo, Panama
from $6,150
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The Panama Canal, Pearl Islands and Darien Jungle

Southbound - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Explore Darien Jungle
  • Visit Portobelo Forts
  • Snorkel Pearl Islands
Starts / Ends
Panama City / Panama City
Activity Level
Variable
Embark on an 8-day Panama Canal, Pearl Islands and Darien Jungle cruise aboard National Geographic. Quest in Colon and explore Panama’s Pacific coast. Cruise Gatun Lake, hike Barro Colorado Island trails, and visit the Pearl Islands. Discover Darien National Park’s rainforest and culture, explore Punta Patiño Reserve, and return to Panama City.
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Blue water and lush rain forest in Panama
from $6,150
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The Panama Canal, Pearl Islands and Darien Jungle

Northbound - 8 Day Itinerary aboard National Geographic Quest
  • Panama Canal transit
  • Chagres River cruise
  • Kayak and snorkel at Isla del Rey
  • Explore Playa Muerto
Starts / Ends
Panama City / Panama City
Activities
Snorkeling, Wildlife Viewing, Village Visits, Hiking, Archaeological Site Visits, Stand Up Paddle Boarding, Kayaking, Rainforest Exploration
Activity Level
Variable
Explore Panama on an 8-day cruise aboard National Geographic Quest. Transit the Panama Canal, anchor in Gatun Lake, and discover Darien National Park and the Pearl Islands. Kayak, hike rainforests, snorkel reefs, and meet Embera communities in remote villages and protected reserves.
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Panama's turquoise waters
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