Top Panama Tours & Cruises in 2027

Set sail on an 8-day cruise from Puntarenas to Colon aboard Le Laperouse. Explore Quepos, Darien National Park, Flamenco Island, the San Blas Islands, and complete the full Panama Canal crossing with cultural encounters and wildlife viewing.

Experience a 15-day expedition cruise from Liberia, Costa Rica, to Panama City, Panama, aboard Safari Voyager. Explore remote national parks, tropical islands, vibrant reefs, and Indigenous communities while kayaking, snorkeling, hiking, and crossing the iconic Panama Canal on an unforgettable small-ship adventure.

Arrive in San Jose, transfer to La Fortuna and start the 9-day land and sea adventure. Explore Arenal Volcano and rainforest trails. Fly to Panama City and embark National Geographic Quest. Kayak, hike, and cruise the Panama Canal, Gatun Lake, and Pearl Islands while snorkeling, exploring fortresses, and discovering tropical wildlife.

Set sail on an 8-day cruise aboard the Star Clipper, starting in Puerto Caldera, Costa Rica. Explore stunning beaches, vibrant marine parks, and rich history before concluding your adventure in Balboa, Panama.

Embark on a 12-day cruise aboard the Sylvia Earle to explore Central America's rich ecosystems, from Costa Rica's diverse wildlife to Panama's vibrant coral reefs. Experience a memorable daylight transit through the historic Panama Canal, witnessing this engineering marvel firsthand.

Sail the Panama Canal on a 10-day Star Clippers cruise through Central America. Begin in Balboa, then transit the Panama Canal and see the locks in action. Explore Spanish forts in Portobelo, meet the Guna people in the San Blas Islands, and discover Colombia’s coastal cities of Cartagena and Santa Marta. Enjoy scenic days under sail.

Set sail on an 8-day cruise aboard the Star Clipper through Costa Rica and Panama, exploring lush rainforests, pristine beaches, and vibrant marine life. Highlights include Manuel Antonio, Coiba Island, and Isla Tortuga’s turquoise waters.

Set sail on an 11-day cruise through Panaman, Colombia and Caribbean Islands aboard Le Bellot. Visit Cartagena and Santa Marta with guided historic and cultural excursions. Explore the San Blas Islands for beaches, snorkeling, and Kuna culture. The voyage combines nature, culture, and Caribbean island experiences.

Experience the essence of “Pura Vida” on a 13-day Panama cruise from Puntarenas to Colon. Visit Punta Leona, Marina Flamingo, Playa Panama, Quepos, Puerto Jimenez, the Pearl Islands, and the San Blas Archipelago, exploring rainforests, beaches, & marinas while encountering diverse wildlife and witnessing the engineering marvel of the Panama Canal.

Experience a 10-day expedition from Callao (Lima), Peru to Colon, Panama aboard MV Discoverer. Explore ancient archaeological sites, Ecuador’s Pacific coast, Colombia’s biodiverse rainforests, and the engineering marvel of the Panama Canal while enjoying wildlife encounters, cultural discoveries, and enriching days at sea.

Join a 14-day cruise on the Scenic Eclipse II along South America's Pacific coast, starting in UNESCO-listed Valparaiso. Explore diverse wildlife, historic sites in Peru and Ecuador, and conclude in Panama’s Darien National Park, a UNESCO biosphere reserve.

This Panama City one-day tour takes you on the incredible journey from the Atlantic Ocean all the way to the Pacific Ocean, traversing two impressive locks via the manmade wonder that is the Panama Canal.