Top South America Trips & Tours in September 2025

from $4,255

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Andes and Amazon

15 Day Itinerary

Activities

Horseback Riding, Spa Relaxation, Whitewater Rafting, Hacienda Visits, Biking

Activity Level

Relaxed

Our most complete tour of Ecuador. Explore colonial Cuenca, the Inca ruins of Ingapirca, and the town of Baños, before descending to Amazon rainforest for three days. Upon returning to the highlands we'll soak in the Papallacta Hot Springs then spend a night at one of Ecuador's finest haciendas in the shadow of Imbabura Volcano near Otavalo.

• Explore the colonial city of Cuenca
• Visit the homes of local weavers
• Hike through the shadowed jungle
• Raft down the Jatunyacu River

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from $2,829

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Manu Wildlife Adventure

6 Day Itinerary

Activity Level

Easy Active

Explore the beauty of the Amazon on a 6-day trip to Manu Wildlife Center in Peru. Watch as tapirs and macaws feed on clay licks, boat down the river and search for nocturnal animals like the caiman on this exciting itinerary. Active opportunities include hikes, canopy towers, boating in oxbow lakes and more.

• Walk along the Collpa Trail
• Watch as toucans fly over head
• Stop to see gold miners

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from $2,424

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Manu Wildlife Snapshot

5 Day Itinerary

Activity Level

Easy Active

Travel to the remote Amazon Rainforest on your trip to Peru. Watch in awe as woodpeckers, tanagers, macaws, toucans and parakeets fly around the treetops on this 5-day adventure at Manu Wildlife Center. Your trip will give you the chance to intimately experience nature from trails, canopy towers, oxbow lakes, and rivers!

• Go to an oxbow lake
• Visit the Tapir Clay lick
• Look for spider monkeys

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from $2,112

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Beautiful Buenos Aires & Iguazu Falls

Tour - 7 Day Itinerary

Activities

Ziplining

Activity Level

Relaxed

Begin this week-long Argentina vacation in metropolitan Buenos Aires before traveling to Iguazu Falls, the world's largest waterfall system at the Argentine-Brazilian border. Enjoy the best Argentina has to offer with visits to local fruit markets at the Tigre Delta, ferry tours, tango shows and of course, Argentine steak & wine.

• Experience an Argentine Tango show
• Enjoy exploring Buenos Aires
• Visit and discover Iguazu Falls
• Explore Tigre Delta

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from $1,915

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Uruguay Beach Escape

4 Day Itinerary

Starts / Ends

Jose Ignacio / Punta del Este

Activities

Wildlife Viewing, Local Market Visits, Urban Exploration, Wine Tasting

Activity Level

Relaxed

On this 4-day Uruguay Beach Escape Tour, discover José Ignacio, Uruguay's equivalent of the Hamptons for locals, where you can escape the urban hustle in style. This small coastal town radiates a unique South American bohemian allure that's simply enchanting. Make sure to secure reservations for all the essential local experiences!

• Explore Punta Del Este City
• Discover La Barra
• Trails to the Anastasio Stream
• Experience the Uruguayan Tuscany

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from $1,740

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Guaviare Adventure

4 Day Itinerary

Starts / Ends

Bogota / Bogota

Activities

Archaeological Site Visits

Activity Level

Easy Active

Embark on a 4-day adventure in San Jose del Guaviare, Colombia. Delve into the Amazon rainforest, exploring ancient rock art at Cerro Azul and the iconic Puerta de Orion. Enjoy boat rides along the Guayabero River, ecological hikes, and possible encounters with pink dolphins. Conclude with a swim in natural pools.

• Discover San Jose del Guaviare
• See rock art mural
• Visit El Raudal via a boat ride
• A chance to encounter pink dolphins

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from $1,670

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Calanoa Amazonas Experience

5 Day Itinerary

Starts / Ends

Bogota / Bogota

Activities

Wilderness Lodge Exploration, Rainforest Exploration, Village Visits

Activity Level

Relaxed

Explore the Amazon rainforest, one of the most biodiverse regions in the world, while staying at an eco-lodge like Calanoa Amazonas during this 5-day Calanoa Amazonas Experience in Colombia. Learn about conservation efforts to preserve wildlife while viewing exotic species and their natural habitats.

• Explore Colombian Amazon
• See exotic plants and animals
• Learn about wildlife conservation
• See the rich culture of Colombia

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from $1,962

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Wild Tambopata

Amazon Tours - 7 Day Itinerary

Activity Level

Relaxed

From the comfort of the Tambopata Research Center, visit the largest known macaw salt lick in the Amazon and travel deep into the wildest area of the Amazon jungle on this engaging 6-night active itinerary into Peru's rainforest. Learn about the nature while hiking the trails and exploring the center from naturalist guides and scientists.

• View Amazon wildlife
• Visit a macaw clay lick
• Take a night walk with your guide
• Stay at Tambopata Research Center

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from $1,439

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Iguazu Falls & Argentine Rainforest

5 Day Itinerary

Activity Level

Relaxed

Experience the world's largest waterfall system - Iguazu Falls - on this amazing 5-day Argentina vacation. Take the "most beautiful thousand meter walk in the world" overlooking the Falls, then search for rainforest wildlife as you spend three nights at Yacutinga Lodge experiencing the subtropical rainforest straddling the Argentina-Brazil border.

• Explore the famous Iguazu Falls
• Spot wildlife at Yacutinga Lodge
• Float the San Francisco River

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from $1,621

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Montevideo Trails of Culture and Wine

3 Day Itinerary

Starts / Ends

Montevideo / Montevideo

Activity Level

Relaxed

Explore Montevideo's wine and culture on a 3-day heritage tour. Delve into museums, landmarks, and wineries. Discover Uruguay's diverse legacy shaped by immigrants over 250 years, blending European flair, family values, African rhythms, indigenous traditions, and gaucho lifestyle, fostering a unique culture.

• Explore Montevideo
• Explore Uruguay
• Learn the culture of Uruguay
• Explore museums in Montevideo

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from $1,441

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Jesuit Missions

5 Day Itinerary

Activity Level

Relaxed

This 5-day tour from Santa Cruz, Bolivia takes you along the circuit of Jesuit Missions once thought to be forgotten, giving you the unique opportunity to visit the magnificent, centuries-old churches that have been restored in San Javier, Concepcion, San Ignacio, San Miguel, San Rafael, and Santa Ana. You'll learn about this history & restoration.

• Explore the Jesuit missions capital
• Visit the mission town, San Javier
• Learn about the restoration project

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from $805

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Explore Colonia

3 Day Itinerary

Starts / Ends

Buenos Aires / Buenos Aires

Activity Level

Relaxed

Discover Colonia del Sacramento, Uruguay, a UNESCO-listed colonial city on a 3-day tour. Explore its unique blend of Portuguese and Spanish architecture, rich history, and stunning natural beauty. Explore historic sites, the harbor, museums, and galleries, and enjoy local cuisine.

• Take the ferry from Buenos Aires
• Explore Rio de la Plata
• Discover architectural styles
• Explore cuisines and local cafés

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from $873

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Sacred Valley Community Clean-Up

2 Day Itinerary

Activity Level

Relaxed

This two-day service oriented trip helps local communities offset the negative consequences of modernization that impacts the Andes. The service project will allow travelers to go into the community and help families collect waste, separate it based on recyclables, biodegradable/compostable waste, and disposable garbage and educate and promote composting and recycling efforts in local communities surrounding the Sacred Valley.

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from $864

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La Paz and Uyuni

4 Day Itinerary

Starts / Ends

La Paz / La Paz

Activity Level

Relaxed

On this 4-day tour, you will get a taste of Bolivia's geographical diversity from volcanos to ancient salt flats. Visit the capital city of La Paz, where you can wander through the colorful markets and marvel at the historic architecture before flying to Uyuni to explore the famous region of the world's largest salt flats, visible from space.

• See giant cacti up to 32-ft tall
• Explore La Paz with your guide
• Visit Uynui Salt Flats

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from $759

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Lake Titicaca - Sun and Moon Islands

3 Day Itinerary

Activity Level

Relaxed

This three day extension allows travelers to spend two nights on Sun Island and visit Moon Island and Copacabana. Explore Lake Titicaca, a geographic landmark and the world's highest navigable and South America's largest lake. According to legend, the son of Inti, the sun god, emerged as the first Inca from the waters of Lake Titicaca.

• Explore Sun Island
• Visit a cathedral
• Trek El Calvario for great views

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from $473

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Huallatakunka Trek

1 Day Itinerary

Activities

Hiking

Activity Level

Easy Active

This full-day trek over Huallatakunka Pass is an exciting way to get to know the local communities here while immersing yourself in nature. You will have a chance to tour a bakery in Oropesa and stop in the Pinipampa community, known for their roof tiles. The maximum altitude you'll reach on this tour is 16,243 feet.

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from $489

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Lake Titicaca - Sun Island & Copacabana

2 Day Itinerary

Activity Level

Relaxed

This overnight Peru extension tour takes you on a 2-day journey to the world's highest navigable lake, Lake Titicaca to spend the night on Sun Island, where you can explore the Inca ruins and climb the ancient stairs of Yumani.

• Visit Inca sites on Sun Island
• Explore Copacabana
• Boat on Lake Titicaca

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from $287

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Healthy Breakfast

½ Day Itinerary

Activities

Volunteering

Activity Level

Relaxed

This 1-day service opportunity from Ollantaytambo takes you first to the market to purchase food followed by a day of distributing it as breakfast in the local communities of Rumira, Pachar, Piri or Camicancha. You will get to know the kids who live in this region along the way.

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