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St. Louis River Cruises

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Experience the vibrant city of St. Louis with Adventure Life's array of 6 diverse Cruises for 2025. Join us on a cruise journey through the iconic Gateway City, where you can immerse yourself in the rich cultural tapestry, explore historic neighborhoods, and marvel at the impressive architecture. From the famous Gateway Arch to the lively riverfront, each moment offers a unique opportunity to discover the essence of this dynamic destination. Engage in urban exploration, food & wine experiences, and scenic river cruises, all while surrounded by the charm and energy that define St. Louis. With tours ranging from , there's something for every traveler seeking a blend of history, culture, and adventure in the heart of the Midwest. Don't miss this chance to delve into the captivating nature, history, and urban vibrancy of St. Louis. Contact one of Adventure Life's St. Louis specialists for help planning your next seamless trip.
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    • St. Louis
Visit the Quad cities, including Davenport, Iowa
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
Starts / Ends
St. Louis / Red Wing
Activity Level
Variable
Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Experience wildlife and nature
  • Admire local artwork in Red Wing
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits, Archaeological Site Visits, Wine Tasting, Urban Exploration, Local Market Visits, Wildlife Viewing, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $4,610
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
Starts / Ends
St. Louis / St. Paul
Activity Level
Variable
Explore the Upper Mississippi River aboard the American Heritage on this 9-day cruise from St. Louis to Minneapolis. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns and take in the diverse scenery.
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Cruise Details
0
Visit historic Minneapolis
from $15,890
Savings
EXPLORE

Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
Starts / Ends
New Orleans / St. Paul
Activity Level
Variable
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony
Starts / Ends
St. Louis / Red Wing
Activities
Cooking Classes
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
  • Explore Mark Twain’s hometown
  • Cruise through historic towns
  • Explore St. Paul's grand mansions
  • Visit National River Museum
Cruise Details
0
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