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Explore the coastlines of the Great Lakes

Marietta Ohio River Cruises

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Experience the charming city of Marietta in Ohio with Adventure Life's selection of 2 diverse cruises for 2026. Join us on a cruise journey along the Ohio River, where you can explore the city's rich history, picturesque architecture, and vibrant culture. Discover the area's fascinating heritage through land tours, village visits, and urban exploration. Whether you're interested in cultural experiences, food & wine tastings, or wildlife viewing opportunities, Marietta offers something for every traveler. From hiking adventures to archaeological site visits, this destination is perfect for those seeking an active and immersive travel experience. Don't miss the chance to sail through the heart of Ohio and uncover the hidden gems of Marietta. Contact one of Adventure Life's tour specialists for help planning your next seamless trip.
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Explore Pittsburgh
from $5,275
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Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Explore Pittsburgh’s rich history
  • Visit historic Marietta, OH
  • Tour Cincinnati’s top sites
  • Experience Louisville Derby legacy
Starts / Ends
Pittsburgh / Louisville
Activities
Small Ship Sailing, Wine Tasting
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Variable
Embark on a 9-day cruise along the Ohio River aboard the American Melody from Pittsburgh to Louisville. Discover historic towns and cultural landmarks while enjoying guided tours, historic excursions, and breathtaking river views as you cruise through America’s heartland.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activities
Urban Exploration, Village Visits, Wildlife Viewing, Archaeological Site Visits
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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