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Explore the coastlines of the Great Lakes

Ohio River Cruises

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Embark on a journey through time in Marietta, Ohio, with our 2 unique archaeological site visits designed for 2026. This city, rich in history and nestled along the confluence of the Muskingum and Ohio rivers, offers an intimate glimpse into America's past. Over a span of 9 to 16 days, you'll engage with the heritage that shaped this region aboard the elegant American Countess during your river cruise. With prices beginning at just $5,275 to $16,230, delve into Marietta's storied museums and uncover historical treasures that tell tales of yesteryear. Savor village visits where local lore comes alive amidst charming Americana culture. To discover more about these immersive experiences that connect you to America’s heartland history, contact one of Adventure Life's trip planners to start planning your next seamless trip.
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    • Marietta
Explore Pittsburgh
from $5,275
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Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Learn Pittsburgh steel city history
  • See Wheeling Victorian architecture
  • Ohio River scenic cruise
  • Visit Louisville Slugger Museum
Starts / Ends
Pittsburgh / Louisville
Activities
Local Market Visits
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Variable
Embark on a 9-day Ohio River cruise from Pittsburgh to Louisville aboard American Melody. Explore Wheeling, Marietta, Cincinnati, Madison, and more. Discover historic architecture, museums, riverfront views, and cultural attractions while enjoying onboard activities, local cuisine, and scenic river landscapes.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
Savings
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activities
Urban Exploration, Archaeological Site Visits, Wildlife Viewing, Village Visits
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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Explore the coastlines of the Great Lakes
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