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Explore the coastlines of the Great Lakes

Ohio River Cruises

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Explore the wonders of Marietta on one of Adventure Life's 2 River Cruises in 2026. Sail along the picturesque rivers, immersing yourself in the rich cultural heritage and stunning landscapes. Navigate through historic sites, charming villages, and vibrant urban centers, where you can explore archaeological sites, enjoy wine tasting, and indulge in delicious local cuisine. From wildlife viewing to hiking adventures, there are activities for every type of traveler. Join us on a trip to Marietta and discover the beauty of this destination on a river cruise. Contact one of our award-winning river cruise experts to start planning your next seamless trip.
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    • Marietta
Explore Pittsburgh
from $5,275
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Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Learn Pittsburgh steel city history
  • See Wheeling Victorian architecture
  • Ohio River scenic cruise
  • Visit Louisville Slugger Museum
Starts / Ends
Pittsburgh / Louisville
Activities
Local Market Visits
Activity Level
Variable
Embark on a 9-day Ohio River cruise from Pittsburgh to Louisville aboard American Melody. Explore Wheeling, Marietta, Cincinnati, Madison, and more. Discover historic architecture, museums, riverfront views, and cultural attractions while enjoying onboard activities, local cuisine, and scenic river landscapes.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activities
Urban Exploration, Archaeological Site Visits, Wildlife Viewing, Village Visits
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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Explore the coastlines of the Great Lakes
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We guide you through every detail beyond the cruise—from flights to pre- and post-trip stays—so your journey feels effortless.

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Receive personal attention and concierge-level service for the same cost as booking direct. Gain access to exclusive rates, perks, and insider expertise on how to maximize the value for your dollar.

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We're not tied to any one cruise line, so you receive honest guidance on the best ship and itinerary for you—not a sales pitch.

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