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Top United States Trips & Tours in October 2025

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Discover United States in October 2025 on one of these 27 tours hand-selected by the travel experts at Adventure Life. Explore the best of during October 2025 as you enjoy Archaeological Site Visits, Urban Exploration, Village Visits, Wildlife Viewing, and Wine Tasting. Prices for trips in October 2025 range from $2,625 to $54,870 for a vacation of 6 to 15 days. Choose any of the below 27 itineraries in October 2025 and customize it when you contact one of Adventure Life's expert United States trip planners.
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Grand Teton National Park
from $3,410
EXPLORE

Yellowstone & Grand Teton Adventure

North America Small Group Tour - 6 Day Itinerary
Starts / Ends
Mountain Modern Motel / Jackson Hole
Activities
Hiking
Activity Level
Easy Active
Learn all about Yellowstone and Grand Teton National Park’s wildlife in this 6-day tour. Visit home to some incredible wildlife such as bison, elk, bears, or wolves as well. This adventure tour includes hiking through forests and plenty of hiking trails waiting to discover.
  • Experience wildlife in Grand Teton
  • Visit National Museum of Wildlife
  • Enjoy adventures of Yellowstone NP
  • Spot wildlife habitats and terrains
Tour Details
0
Visit Louisiana's capital city of Baton Rouge
from $3,990
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
  • Experience Natchez’s beauty
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Cruise Details
0
Columbia River Gorge
from $4,105
Savings
EXPLORE

Highlights of the Columbia River

Portland Roundtrip - 6 Day Itinerary aboard American Pride
Starts / Ends
Portland / Portland
Activity Level
Variable
Embark on a 6-day Columbia River cruise aboard American Pride. This journey offers direct access to local culture, history, and Pacific Northwest landscapes.
  • Discover Astoria’s maritime history
  • Discover Native history
  • See Multnomah Falls cascade
  • Learn Mount St. Helens eruption
Cruise Details
0
Scenic Landscape
from $6,409
EXPLORE

Columbia and Snake Rivers: Food, Wine, and History - Eastbound

Portland - Clarkston - 8 Day Itinerary aboard National Geographic Sea Lion
Activities
Biking
Activity Level
Variable
The Sea Lion hosts this 8-day excursion from Portland, Oregon towards Clarkston, Washington. Along the way, pass through Hells Canyon, visit the Lewis and Clark Wildlife Refuge, zodiac & kayak your way along the Palouse River, and witness the Columbia River Gorge.
  • Bike or walk along the river
  • Zodiak or kayak the Palouse River
  • Jet boat through Hells Canyon
  • Explore the Lewis & Clark Refuge
Cruise Details
0
Columbia River Gorge
from $4,125
Savings
EXPLORE

Columbia River Gorge Cruise

Roundtrip Portland - 7 Day Itinerary aboard American Pride
Starts / Ends
Portland / Portland
Activities
Wine Tasting, Small Ship Sailing
Activity Level
Variable
Set sail on a 7-day Columbia River Gorge cruise aboard American Pride. Explore Portland, Hood River, The Dalles, and Kalama. Discover the pioneers at the Oregon Trail’s end and learn about the region’s history at museums like the Columbia Gorge Discovery Center and the Fort Dalles Museum.
  • Discover Hood River’s museums
  • Walk through The Dalles
  • Visit Mount St. Helens
  • Taste local wines from Hood River
Cruise Details
0
The still water of the Palouse River
from $5,827
EXPLORE

Columbia and Snake Rivers: Food, Wine, and History

Fall Season - 8 Day Itinerary aboard National Geographic Sea Bird
Activity Level
Variable
The Sea Bird takes you on this 8-day Pacific Northwest cruise along the Columbia and Snake Rivers, including zodiac & kayak excursions, hiking and biking opportunities, and visits to the Lewis and Clark Wildlife Refuge, the Columbia River Gorge, and Hells Canyon.
  • Trek up the iconic Beacon Rock
  • Zodiak or kayak the Palouse River
  • Jet boat through Hells Canyon
  • Explore the Lewis & Clark Refuge
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
from $13,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Cruise Details
0
Vicksburg Battlefield overlooking the Mississippi River
from $7,499
EXPLORE

Mississippi Delta Explorer

New Orleans - Memphis - 8 Day Itinerary aboard Viking Mississippi
Starts / Ends
New Orleans / Memphis
Activities
Village Visits
Activity Level
Variable
On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.
  • Explore Darrow
  • Visit Natchez historic sites
  • Learn the history of Vicksburg
  • Culinary adventure of Mississippi
  • Know the history of rock 'n' roll
  • American South's Cultural Heritage
Cruise Details
0
Columbia River Gorge
from $6,400
Savings
EXPLORE

Columbia & Snake Rivers Cruise

Portland - Clarkston - 9 Day Itinerary aboard American Song
Starts / Ends
Portland / Richland
Activity Level
Variable
Embark on a 9-day cruise aboard American Song, navigating the Columbia & Snake Rivers. Cruise past Mount Hood, reliving the golden age of riverboats. Explore Astoria's Victorian charm and visit Fort Clatsop. Journey through history in The Dalles, Richland, and Pendleton, culminating in the majestic landscapes of Hells Canyon.
  • Explore Astoria's Victorian charm
  • Step ashore in Kalama
  • Discover Richland's scenic trails
  • Cruise the legendary Snake River
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,995
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
Starts / Ends
St. Louis / Red Wing
Activities
Cooking Classes
Activity Level
Variable
Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Experience wildlife and nature
  • Admire local artwork in Red Wing
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
from $4,925
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Splendor
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Sunken Garden at Butchart Garden, British Columbia
from $5,425
Savings
EXPLORE

Puget Sound & San Juan Islands Cruise

Roundtrip Seattle - 8 Day Itinerary aboard American Constellation
Starts / Ends
Seattle / Seattle
Activities
Whale Watching
Activity Level
Variable
Embark on an 8-day adventure to Puget Sound and the San Juan Islands aboard American Constellation. Cruise to historic coastal towns. Explore wildlife and scenic beauty with excursions to Butchart Gardens and Olympic National Park.
  • Visit Anacortes
  • Traverse the San Juan Islands
  • Visit Butchart Gardens
  • See wildlife in San Juan Islands
Cruise Details
0
Explore beautiful Nashville
from $5,275
Savings
EXPLORE

Tennessee Rivers Cruise

Nashville to Chattanooga - 9 Day Itinerary aboard American Symphony
Starts / Ends
Nashville / Chattanooga
Activities
Archaeological Site Visits, Urban Exploration, Local Market Visits
Activity Level
Variable
Set sail on a 9-day Tennessee Rivers Cruise from Nashville to Chattanooga aboard American Symphony. Relax with expert talks, regional cuisine, and comfortable accommodation while exploring the history, culture, and natural beauty of America’s heartland.
  • Explore Nashville’s music landmarks
  • Visit Paducah’s Quilt Museum
  • Walk historic Shiloh battlefield
  • Cruise through Appalachian scenery
Cruise Details
0
View monuments from the Civil War in Mississippi
from $4,925
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Enjoy the scenery of the Great Lakes
from $7,999
EXPLORE

Great Lakes and St. Lawrence Seaway

Chicago - Montreal - 13 Day Itinerary aboard Victory I
Starts / Ends
Chicago / Montreal
Activity Level
Variable
Sail from Chicago to Montreal on a 13-day cruise aboard Victory I, exploring iconic cities, engineering marvels, and natural wonders. Scenic lake crossings offer time to unwind between dynamic destinations.
  • Visit Willis Tower in Chicago
  • Explore the Henry Ford Museum
  • Visit Rock and Roll Hall of Fame
  • Discover Toronto's culture
Cruise Details
0
Hatley Castle, Victoria
from $5,897
EXPLORE

Exploring British Columbia and the San Juan Islands

8 Day Itinerary aboard National Geographic Venture
Starts / Ends
Seattle / Seattle
Activities
Kayaking
Activity Level
Variable
Discover the powerful wilderness and warm charm of the Pacific Northwest over a wide-ranging week in the San Juan Islands and British Columbia on an 8-day expedition cruise aboard National Geographic Venture. Explore remote islands and sail through channels that teem with sea life and visit charming towns and First Nations heritage sites.
  • Learn the histories of First Nation
  • Search for killer whales
  • Enjoy a private evening event
  • Kayak and hike the wildlife coasts
Cruise Details
0
Explore the Snake River in the Pacific Northwest of the US
from $6,715
Savings
EXPLORE

Columbia & Snake Rivers Cruise

Clarkston to Portland - 9 Day Itinerary aboard American Jazz
Starts / Ends
Clarkston / Portland
Activities
Wildlife Viewing
Activity Level
Variable
Embark on an unforgettable 9-day Columbia & Snake Rivers cruise aboard American Jazz. Experience scenic landscapes, historic towns, and diverse wildlife. Highlights include traveling through Hells Canyon, Columbia River Gorge, and Mount St. Helens.
  • Visit Multnomah Falls
  • Explore vineyards and local artwork
  • Witness volcanic remains
  • Sail through Hells Canyon
Cruise Details
0
Vanderbilt Mansion National Historic Site
from $7,430
Savings
EXPLORE

Hudson River Fall Foliage

New York - New York - 8 Day Itinerary aboard American Glory
Starts / Ends
New York / Catskill
Activity Level
Variable
Embark on a scenic Hudson River 8-day cruise from New York to Albany aboard American Glory. Visit historic sites in Sleepy Hollow, West Point, Kingston, Hyde Park, and Catskill. Enjoy scenic views, onboard enrichment, and cultural landmarks. Experience the beauty and history of the Hudson River on this unforgettable journey.
  • Visit Sleepy Hollow landmarks
  • Tour West Point Academy
  • Discover Hyde Park’s history
  • Admire Vanderbilt Mansion
Cruise Details
0
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