Have questions? We're here.
Bright blue waters of the Caribbean sea

Panama City Cruises

Travel made your way ™
Talk with an expert
Build your ideal Panama trip. Call 1.406.541.2677
Start Planning My Trip
Talk with an expert
Experience the captivating allure of Panama City with Adventure Life's array of 3 Cruises for 2025. Join us on a cruise journey through this vibrant destination, where you can explore the juxtaposition of modern skyscrapers and historic neighborhoods, discover the rich cultural tapestry of Panama's capital, and marvel at the engineering marvels of the Panama Canal. From urban exploration to wildlife viewing in the surrounding rainforests, each moment offers a unique opportunity to immerse yourself in the wonders of this diverse city. Engage in local market visits, historical site explorations, and village tours, all while surrounded by the natural beauty that Panama City has to offer. With 3 tours to choose from, embark on an adventure to Panama City today and contact one of Adventure Life's tour specialists for help planning your next seamless trip.
Filter (3 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Panama City
Crossing a stream on Osa Peninsula
from $11,295
EXPLORE

Costa Rica & Panama Canal

Costa Rica - Colombia - 12 Day Itinerary aboard Greg Mortimer
  • Explore Costa Rica's wildlife
  • Discover vibrant bird species
  • Learn about the Emberá tribe
  • Cross the Panama Canal
  • Visit Curú National Wildlife Refuge
Starts / Ends
San Jose / Colon
Activities
Stand Up Paddle Boarding, Wildlife Viewing, Snorkeling, Village Visits, Archaeological Site Visits, Photography Seminars, Scuba Diving, Whale Watching
Activity Level
Variable
Embark on a 12-day Costa Rica & Panama Canal Cruise with travel photographer Richard I'Anson. Explore Costa Rica's rainforests, and Panama's coral reefs, connect with the Emberá tribe, and delve into Panama Canal's history.
Cruise Details
0
Trekking through Corcovado National Park in Costa Rica.
from $7,315
EXPLORE

Costa Rica and the Panama Canal

San Jose - Panama - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Horseback Riding, Kayaking
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
0
Zapatilla Cay, Panama
from $6,741
Save 20%
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, San Bernardo Archipelago, and more.
Cruise Details
0
1-3 of 3 Results
  • 1

Panama Travel Guide

Top Panama Travel Destinations

Panama Trips by Departure Date

Top Experiences in Panama

Panama Trips by Duration

Panama Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By

Franny Friesz Adventure Life employee profile
Franny F
Plan My Trip
We love travel, talk with an expert 1.800.344.6118