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Panama City Cruises

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Experience the captivating allure of Panama City with Adventure Life's array of 4 Cruises for 2025. Join us on a cruise journey through this vibrant destination, where you can explore the juxtaposition of modern skyscrapers and historic neighborhoods, discover the rich cultural tapestry of Panama's capital, and marvel at the engineering marvels of the Panama Canal. From urban exploration to wildlife viewing in the surrounding rainforests, each moment offers a unique opportunity to immerse yourself in the wonders of this diverse city. Engage in local market visits, historical site explorations, and village tours, all while surrounded by the natural beauty that Panama City has to offer. With 4 tours to choose from, embark on an adventure to Panama City today and contact one of Adventure Life's tour specialists for help planning your next seamless trip.
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    • Panama City
Panama Canal
from $7,461
EXPLORE

Costa Rica and the Panama Canal

Eastbound - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Land & Sea Exploration, Horseback Riding
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
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Guests explore by zodiac cruise in Portobelo, Panama
from $7,389
Save 60%
EXPLORE

The Panama Canal, Pearl Islands and Darien Jungle

Southbound - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Explore Darien Jungle
  • Visit Portobelo Forts
  • Snorkel Pearl Islands
Starts / Ends
Panama City / Balboa
Activities
Hiking, Snorkeling, Wildlife Viewing, Kayaking, Stand Up Paddle Boarding, Village Visits, Urban Exploration
Activity Level
Variable
Embark on an 8-day Panama Canal cruise to the Pearl Islands and Darien Jungle aboard the National Geographic Quest. Transit the legendary Panama Canal, meet the Emberá people in Playa Muerto, spot wildlife in Punta Patiño, and snorkel the clear waters of the Pearl Islands, including Isla del Rey and Isla Pacheca.
Cruise Details
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Paradise Tropical Island - Bocas del Toro archipelago - Island Colon
from $24,990
EXPLORE

Pristine Islands of the Bahamas & the Panama Canal

Nassau - Panama City - 11 Day Itinerary aboard Scenic Eclipse
  • Explore Nassau’s colonial streets
  • Visit Staniel Cay’s beaches
  • Discover San Salvador’s coral reefs
  • Meet Cabo de La Vela’s Wayuu people
Starts / Ends
Nassau / Panama City
Activities
Small Ship Sailing
Activity Level
Variable
Join an 11-day cruise from Nassau to Panama City on the Scenic Eclipse, exploring the Bahamas' clear waters and vibrant island cultures. Experience highlights like Pig Beach and the Panama Canal, blending leisure with cultural discovery.
Cruise Details
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Sunset over Cartagena, Colombia
from $6,810
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activities
Archaeological Site Visits
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, Archipelago, and more.
Cruise Details
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