Have questions? We're here.
Bridge across the Mississippi at Cape Girardeau

Top Cape Girardeau Cruises & Trips

Travel made your way ™
Talk with an expert
Build your ideal Mississippi River trip. Call 1.406.541.2677
Start Planning My Trip
Talk with an expert
Explore these 1 top Cape Girardeau cruises for 2025 and 2026. Some of the most popular activities on our Cape Girardeau trips include Archaeological Site Visits, Local Market Visits, Urban Exploration, Village Visits, and Wine Tasting. Discover with your expert local English-speaking guides who will show you the hot spots and the off-the-beaten-path hidden gems. We work with only the best small ships that carry under 500 fortunate guests, and we can give you unbiased advice to match you with the perfect ship and perfect cruise for your next vacation. Our Cape Girardeau cruises start from $15,890 for cruises of 23 days. Contact one of Adventure Life's Cape Girardeau cruise specialists for help planning a seamless trip.
Filter (1 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Cape Girardeau
Visit historic Minneapolis
from $15,890
Savings
EXPLORE

Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends
New Orleans / St. Paul
Activities
Urban Exploration, Village Visits, Wine Tasting, Local Market Visits, Archaeological Site Visits
Activity Level
Variable
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
Cruise Details
0
1-1 of 1 Results
  • 1

Top Mississippi River Travel Destinations

Mississippi River Trips by Departure Date

Mississippi River Trips by Duration

More Reasons

Why Travel With Adventure Life

All News

Recognized By

Tilly Pearson employee headshot
Tilly P
Plan My Trip
We love travel, talk with an expert 1.800.344.6118
GOT IT!
We use cookies to give you the best experience on our website. Continue browsing the site if you're ok with this. For more info, please see our privacy policy.