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Ship in the Panama Canal

Cruises through the Panama Canal

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Experience the wonders of the Panama Canal with our 17 enriching cruises through the Panama Canal for 2026. Join us on a cruise journey through this engineering marvel. Build a custom trip in Panama around the Panama Canal cruise with our Panama Trip Planners. Add in wildlife viewing, village visits, and hiking adventures while surrounded by the natural splendor that has inspired explorers for centuries. Panama Canal cruises ranging from , there's something for every traveler seeking a blend of adventure and relaxation. Don't miss this chance to navigate the Panama Canal and discover the hidden gems of Central America. Contact one of Adventure Life's Panama specialists for help planning your next seamless trip.
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Guests explore by zodiac cruise in Portobelo, Panama
from $6,150
HALF DEP
EXPLORE

The Panama Canal, Pearl Islands and Darien Jungle

Southbound - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Explore Darien Jungle
  • Visit Portobelo Forts
  • Snorkel Pearl Islands
Starts / Ends
Panama City / Panama City
Activity Level
Variable
Embark on an 8-day Panama Canal, Pearl Islands and Darien Jungle cruise aboard National Geographic. Quest in Colon and explore Panama’s Pacific coast. Cruise Gatun Lake, hike Barro Colorado Island trails, and visit the Pearl Islands. Discover Darien National Park’s rainforest and culture, explore Punta Patiño Reserve, and return to Panama City.
Cruise Details
0
Blue water and lush rain forest in Panama
from $6,150
HALF DEP
EXPLORE

The Panama Canal, Pearl Islands and Darien Jungle

Northbound - 8 Day Itinerary aboard National Geographic Quest
  • Panama Canal transit
  • Chagres River cruise
  • Kayak and snorkel at Isla del Rey
  • Explore Playa Muerto
Starts / Ends
Panama City / Panama City
Activities
Snorkeling, Kayaking, Hiking, Stand Up Paddle Boarding
Activity Level
Variable
Explore Panama on an 8-day cruise aboard National Geographic Quest. Transit the Panama Canal, anchor in Gatun Lake, and discover Darien National Park and the Pearl Islands. Kayak, hike rainforests, snorkel reefs, and meet Embera communities in remote villages and protected reserves.
Cruise Details
0
Ocean view of the edge of Manuel Antonio National Park, Costa Rica
from $6,450
EXPLORE

The Natural Wonders of Central America – with Smithsonian Journeys

Colon to Puntarenas - 8 Day Itinerary aboard Le Bougainville
  • Visit San Blas Islands
  • Cross Panama Canal locks
  • Discover Balboa waterfront district
  • Reach Puntarenas Pacific coast
Starts / Ends
Colon / Puntarenas
Activities
Wildlife Viewing, Rainforest Exploration, Local Market Visits
Activity Level
Variable
Explore Panama and Costa Rica on an 8-day voyage aboard Le Bougainville. Visit Colon, Portobelo, the San Blas Islands, Balboa, Quepos, and Puntarenas. Cross the Panama Canal, discover Afro-Caribbean heritage, meet Indigenous communities, relax at sea, and experience rainforest-lined Pacific shores.
Cruise Details
0
Clear waters of the Caribbean sea
from $7,170
EXPLORE

Panama and Costa Rica by Sea - with Smithsonian Journeys

Puntarenas to Colon - 8 Day Itinerary aboard Le Laperouse
  • Explore Darien National Park
  • Embera village visit
  • See Miraflores Locks view
  • Experience Guna community encounter
Starts / Ends
Puntarenas / Colon
Activity Level
Variable
Set sail on an 8-day cruise from Puntarenas to Colon aboard Le Laperouse. Explore Quepos, Darien National Park, Flamenco Island, the San Blas Islands, and complete the full Panama Canal crossing with cultural encounters and wildlife viewing.
Cruise Details
0
Panama Canal
from $5,772
HALF DEP
EXPLORE

Costa Rica and the Panama Canal

Eastbound - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activity Level
Variable
Discover Costa Rica & Panama on this 8-day cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
0
Explore beautiful Costa Rica
from $6,801
HALF DEP
EXPLORE

Exploring Arenal Volcano, Pearl Islands and the Panama Canal

San Jose to Panama - 9 Day Itinerary aboard National Geographic Quest
  • Arenal Volcano exploration
  • Relax in Ecotermales hot springs
  • Pearl Islands snorkeling
  • Navigate the Panama Canal
Starts / Ends
San Jose / Panama City
Activities
Land & Sea Exploration
Activity Level
Variable
Arrive in San Jose, transfer to La Fortuna and start the 9-day land and sea adventure. Explore Arenal Volcano and rainforest trails. Fly to Panama City and embark National Geographic Quest. Kayak, hike, and cruise the Panama Canal, Gatun Lake, and Pearl Islands while snorkeling, exploring fortresses, and discovering tropical wildlife.
Cruise Details
0
Boats Moored to the Quay at Bridgetown Harbour
from $4,450
EXPLORE

Barbados to Panama

15 Day Itinerary aboard Royal Clipper
  • Explore Bridgetown, Barbados
  • Enjoy Grenada's unique aromas
  • Discover Dutch colonial Curacao
  • Transit the historic Panama Canal
Starts / Ends
Bridgetown / Balboa
Activity Level
Variable
Starting at the Caribbean port of Bridgetown, this 15-day cruise aboard the Royal Clipper sails through the turquoise Caribbean waters en route to the Panama Canal, visiting Grenada, Bonaire, Curacao, Aruba, and Colombia along the way. Explore the tropical jungles, snorkel in vibrant reefs, immerse yourself in tribal culture, and marvel at the Panama Canal.
Cruise Details
0
Panama Canal
from $14,495
EBD
EXPLORE

Costa Rica and The Panama Canal

San Jose - Panama - 12 Day Itinerary aboard Sylvia Earle
  • Cross Panama Canal
  • Explore biodiverse rainforests
  • Visit Coiba National Park
  • Enjoy Manuel Antonio National Park
Starts / Ends
San Jose / Panama City
Activity Level
Variable
Embark on a 12-day cruise aboard the Sylvia Earle to explore Central America's rich ecosystems, from Costa Rica's diverse wildlife to Panama's vibrant coral reefs. Experience a memorable daylight transit through the historic Panama Canal, witnessing this engineering marvel firsthand.
Cruise Details
0
San Blas
from $7,790
EXPLORE

Secrets of Central America

Colon - Puntarenas - 11 Day Itinerary aboard Le Bellot
  • Learn Fort San Lorenzo's history
  • See San Blas Islands' marine life
  • Experience Coiba Island adventure
  • Witness Drake Bay rainforest
Starts / Ends
Colon / Puntarenas
Activity Level
Variable
Explore Panama and Costa Rica aboard Bellot on an 11-day cruise. Sail through the Panama Canal, visit Fort San Lorenzo, the San Blas Islands, Pearl Islands, Darién National Park, Coiba Island, Rio Esquinas, Drake Bay, and Curú Wildlife Refuge. Experience wildlife viewing, Zodiac landings, and cultural encounters with indigenous communities.
Cruise Details
0
Balboa
from $3,150
EXPLORE

Panama to Aruba

12 Day Itinerary aboard Star Clipper
  • Transit the Panama Canal locks
  • Walk colonial Balboa streets
  • Explore forts in Portobelo
  • Visit San Blas and Guna villages
  • See Cartagena and Santa Marta
Starts / Ends
Balboa / Oranjestad
Activities
Small Ship Sailing
Activity Level
Variable
Sail the Panama Canal on a 10-day Star Clippers cruise through Central America. Begin in Balboa, then transit the Panama Canal and see the locks in action. Explore Spanish forts in Portobelo, meet the Guna people in the San Blas Islands, and discover Colombia’s coastal cities of Cartagena and Santa Marta. Enjoy scenic days under sail.
Cruise Details
0
Sunset over Cartagena, Colombia
from $6,450
HALF DEP
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

Panama to Cartagena - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, Archipelago, and more.
Cruise Details
0
Relax on the shores of the Caribbean
from $12,295
Save $150
EXPLORE

Grenadines, Colombia & Panama Canal Transit

Bridgetown - Panama City - 12 Day Itinerary aboard Emerald Azzurra
  • Explore Bequia Caribbean lifestyle
  • Admire Cartagena Old Town
  • See San Blas Islands nature
  • Navigate the Panama Canal
Starts / Ends
Bridgetown / Panama City
Activities
Archaeological Site Visits, Village Visits, Urban Exploration
Activity Level
Variable
Set sail on a 12-day Caribbean cruise from Bridgetown aboard the Emerald Azzurra, exploring islands like Bequia and Mayreau. Conclude your journey in Panama City after traversing the historic Panama Canal and enjoying vibrant local cultures and stunning coastal views.
Cruise Details
0
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Panama

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