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Panama City Tours & Cruises

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Discover the vibrant city of Panama City with Adventure Life on our 7 diverse tours and cruises for 2026. Nestled at the crossroads of the Americas, Panama City offers a rich tapestry of history, culture, and natural beauty waiting to be explored. From the iconic Panama Canal to the charming Casco Viejo district, our itineraries seamlessly blend urban exploration, wildlife viewing, and cultural immersion, providing a deep understanding of this dynamic destination. Over 5 to 9 days, you can delve into Panama City's fascinating blend of old and new, with opportunities for archaeological site visits, local market explorations, and village encounters that showcase the diverse tapestry of Panamanian life. With a range of activities such as hiking, wildlife spotting, and food & wine experiences, there's something for every type of traveler. Starting at $285, embark on a journey that unveils the magic of Panama City's unique charm and allure. To craft a personalized itinerary and experience the best of Panama City in 2026, contact one of Adventure Life's Panama City specialists for help planning your next seamless trip.
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Canopy Tree Trek, Scenery with Forest and Waterfall. Boquete, Panama
from $2,461
EXPLORE

Panama Adventure

8 Day Itinerary
  • Hike through tropical forest
  • Take a coffee tour in Boquete
  • Explore the Golf of Chiriqui
  • Snorkel, kayak or hike
Starts / Ends
Panama City / Crowne Plaza Panama Airport
Activity Level
Easy Active
Discover unique wildlife in the vibrant jungles of western Panama as well as charming Caribbean towns through this comprehensive Panama tour. Explore the country through rainforest hikes, urban explorations, and snorkeling outings. Enjoy a remarkable and truly fresh cup of locally grown coffee at the end of the day!
Tour Details
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Cathedral of Casco Viejo
from $311
EXPLORE

Explore Panama City

½ Day Itinerary
  • Tour the ruins of Panama La Vieja
  • Watch a transit of the Panama Canal
Activities
Urban Exploration
Activity Level
Relaxed
Tour Panama City with a local guide, well versed in the history of the area. See a transit of the Panama canal and tour Casco Antiguo where the pirate Henry Morgan waged his attack in 1671.
Tour Details
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Capuchin monkey
from $285
EXPLORE

Barro Colorado Island Tour

1 Day Itinerary
Activity Level
Easy Active
Visit Barro Colorado Island while in the Panama City with a boat ride in Gatún Lake. Enjoy a day exploring the Smithsonian Tropical Research Institute and learn about the current studies underway. This man-made island was created when the canal was flooded preserving a breathtaking array of diverse wildlife and jungle on the tiny island.
Tour Details
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El Valle de Anton Valley
from $360
EXPLORE

El Valle de Anton

1 Day Itinerary
Activities
Ziplining, Local Market Visits
Activity Level
Moderate
Tour Details
0
Tranquilo Bay indeed...
from $3,787
EXPLORE

Caribbean Adventure

Tranquilo Bay - 9 Day Itinerary
  • Raft down the Pacuare River
  • Hike into the jungle for a swim
  • Marvel at the Panama Canal
  • Snorkel, kayak, hike, or relax
Activities
Whitewater Rafting, Rainforest Exploration, Hiking
Activity Level
Easy Active
Experience the Caribbean from Costa Rica to Panama on this 9-day land-based adventure tour. Whitewater rafting and rainforest exploration along Costa Rica's Pacuare River combine with relaxation amidst the turquoise waters of Panama. Climb into the rainforest canopy, bask in the sunshine of Bocas del Toro, and snorkel & dive among the Caribbean reefs!
Tour Details
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Trekking through Corcovado National Park in Costa Rica.
from $7,315
EXPLORE

Costa Rica and the Panama Canal

San Jose - Panama - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Snorkeling, Stand Up Paddle Boarding, Horseback Riding, Kayaking
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
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Zapatilla Cay, Panama
from $6,741
Save 20%
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activities
Wildlife Viewing
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, San Bernardo Archipelago, and more.
Cruise Details
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