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Top Ohio River Tours & Cruises in 2025

Name: United States Tours & Travel
Brand: Adventure Life
Rating: 4.8 (541 reviews)

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Discover the best the world has to offer with Adventure Life’s expert-curated Ohio River tours 2025. From Paducah, Cincinnati, Louisville, Madison, and Marietta to hidden gems off the beaten path, our 3 top-rated itineraries take you deep into Ohio River’s breathtaking landscapes. Guided by bilingual experts, these immersive experiences cater to adventurers seeking unique journeys in small groups or customizable private tours.

Choose from a variety of 9 days itineraries starting at $4,915 to $9,345. You’ll find options that suit your travel style. Whether you’re passionate about Urban Exploration, Archaeological Site Visits, Local Market Visits, Small Ship Sailing, and Village Visits or eager to explore Ohio River’s rich culture and natural beauty, our Ohio River tours 2025 deliver unforgettable moments. Each itinerary blends awe-inspiring exploration with a commitment to sustainability to ensure your adventure supports the preservation of our planet.

Adventure Life’s dedication to personalized travel promises your Ohio River tour 2025 is seamless from start to finish. From arranging transportation to selecting accommodations tailored to your preferences, we’ll take care of every detail. Our expert recommendations and insider tips make your journey even more enriching.

Contact our specialists today to start planning your Ohio River tour 2025. Whether you’re a solo traveler, a couple, or part of a group, Adventure Life will create a transformative experience you’ll treasure forever.

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- Variable
Experiences
- Active
- Cruises
- Cultural
- River Cruises
- Small Ship Cruises
Activities
- Wine Tasting
- Archaeological Site Visits
- Local Market Visits
- Small Ship Sailing
- Urban Exploration
- Village Visits
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- American Symphony
- American Melody
Destinations
- Ohio River

from $5,275

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Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody

Starts / Ends: Pittsburgh / Louisville
Activities: Small Ship Sailing, Wine Tasting, Village Visits
Activity Level: Variable

Embark on a 9-day cruise along the Ohio River aboard the American Melody from Pittsburgh to Louisville. Discover historic towns and cultural landmarks while enjoying guided tours, historic excursions, and breathtaking river views as you cruise through America’s heartland.

Explore Pittsburgh’s rich history
Visit historic Marietta, OH
Tour Cincinnati’s top sites
Experience Louisville Derby legacy

Cruise Details

from $4,915

Savings

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Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony

Starts / Ends: Memphis / Nashville
Activity Level: Variable

Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in local music, nightly entertainment, and Southern cuisine amid America's heartland's scenic beauty.

Explore Memphis
Discover Paducah
Experience Lake Barkley
Enjoy Nashville

Tennessee Rivers Cruise

Nashville to Chattanooga - 9 Day Itinerary aboard American Symphony

Starts / Ends: Nashville / Chattanooga
Activities: Urban Exploration, Local Market Visits, Archaeological Site Visits
Activity Level: Variable

Set sail on a 9-day Tennessee Rivers Cruise from Nashville to Chattanooga aboard American Symphony. Relax with expert talks, regional cuisine, and comfortable accommodation while exploring the history, culture, and natural beauty of America’s heartland.

Explore Nashville’s music landmarks
Visit Paducah’s Quilt Museum
Walk historic Shiloh battlefield
Cruise through Appalachian scenery

Cruise Details

1-3 of 3 Results

TrustScore 4.8 | 541 reviews

TrustScore 4.8 of 5

Based on 541 reviews on

5 days ago

Betty was very helpful and answered my questions about the UnCruise trip we were interested in.

Judy Cooper

8 months ago

Tony and Shannon were always quick to answer my questions and requests. They booked my Upper Mississippi cruise perfectly. They made sure that my dietary needs were met which is a big deal for me. I have the utmost confidence with their assistance.

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